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Richter transformation continues to be an ominous celebration for sufferers with CLL, specifically when it's clonally connected with the first CLL, mainly because none of the a short while ago permitted novel agents is actually powerful. Certainly, sickness transformation is a relatively popular reason for failure to reap the benefits of these drugs.90,128,129 Histological affirmation is always advisable as it can guidebook prognosis (i.e., Hodgkin lymphoma and clonally unrelated tumors have more favorable prognosis).

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